ceesdekker.net - An Overview
ceesdekker.net - An Overview
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Using one-molecule optical and AFM imaging and power-spectroscopy methods, we seek to unravel the mechanistic components of the framework and dynamics of chromosomes. Our study pursuits include things like:
Reconstitution of ultrawide DNA origami pores in liposomes for transmembrane transport of macromolecules
‘It was simply just a subject of selecting up a guide on mobile biology and starting to study. I'd come from a globe of extremely-substantial vacuums, cryostats and quantum phenomena, and now I used to be working at home temperature with molecular biology kits.
Sculpting nano-electrodes using a transmission electron beam for electrical and geometrical characterization of nanoparticles.
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Microbiology has only been around for any century, considering that we began to review micro-organisms additional very seriously. I assumed nanobiology was an acceptable expression, for the reason that all molecular Organic applicable interactions occur within the nanoscale: a protein is a couple of nanometres in dimension, DNA is 2 nm thick.’
‘Initially we looked at Organic units using a Bodily perspective and acted on the basis in the applications we knew. It took a few years ahead of we begun working a lot more on the large Organic problems. I then started to phone it nanobiology, a time period that didn't exist at some time.
2011, 1st in vitro measurements of transport across a single biomimetic nuclear pore complicated; improvement of multiplexed magnetic tweezers for kilo-molecule experiments; and resolved the system of homology recognition in DNA homologous recombination
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one). The present–voltage curves confirmed considerable modulations with gate voltage, even at home temperature, which was in keeping with band bending inside a ~0.six eV bandgap semiconducting nanotube. These data also showed which the conductance could possibly be modulated by 6 orders of magnitude by changing the gate voltage. The outcome of the function — a place-temperature transistor produced from one carbon nanotube molecule — were being printed in Mother nature in May 1998.
Since 2000 he moved to one-molecule biophysics and nanobiology, with investigation from research of DNA loop extrusion and supercoiling to DNA translocation as a result of nanopores. A lot more recently his exploration has focused on finding out chromatin structure and cell division with bacteria on chip, even though he is also aiming to ultimately Create synthetic cells from the bottom up.
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It was an extremely attention-grabbing time, throughout which I acquired a lot of assist from Delft University of Technological innovation, where by I was a professor at the time, and I commenced quite a few collaborations with molecular biologists. That helped me discover a good deal.’